Liverpool must overcome a 1-0 deficit from the first leg to keep alive their hopes of winning some silverware this season, before a crunch clash at Manchester United on Sunday.
At the moment, Liverpool are 5th placed in the Premier League with 51 points, after their last 4-1 victory over Portsmouth, the bottom club.
Lille are 4th placed in their domestic league, the Ligue 1, with 51 points, just 2 points from the leader, Bordeaux.
Eden Hazard, who scored the winner in the first leg, is set to be Lille's main danger with Pierre-Alain Frau again ploughing a lone furrow in attack.
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